Chemical composition and antibacterial activities of the soft coral Lobophytum sp.from the South China Sea
To investigate the chemical composition and biological activity of the soft coral Lobophytum sp.collected from South China Sea.A series of methods such as silica gel column chromatography,thin-layer chromatography,Sephadex LH-20 column chromatography,and semi-preparative high performance liquid chromatography were used to separate and purify.The structure of the compounds was characterized by analysis of NMR data and comparison with the data reported in literature.Twelve compounds were identified from the soft coral Lobophytum sp.,including nine diterpenoids:(+)-(7R,8R)-epoxy-7,8-dihydrocembrene C(1),(1R,2E,4R,7E,11E)-cembra-2,7,11-triene-4-ol(2),(-)-(2R,7R,8R)-sarcophytoxide(3),entsarcophine(4),sarcotenusene C(5),(7S,8S)-epoxy-1,3,11-cembratrien-16-oic methyl ester(6),sarcophytonin B(7),sarcoconvolutum D(8),laevigatol A(9);three steroids:campesterol(10),(24S)-24-methylcholesterol(11),gorgonol(12).Compound 8 was isolated from the soft coral Lobophytum sp.for the first time.The bioassay results revealed that compounds 3,4,5,7 and 10 show significant antibacterial activity against fish pathogens Photobacterium damselae FP2244,oxytetracycline-resistant Streptococcus parauberis SPOF3K,and human pathogen vancomycin-resistant Enterococcus faecium.
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