In order to understand the causes of fruit quality differences in Momordica charantia,the contents of cell wall components and related enzyme activities in thick flesh-type'LX1-3'and thin flesh-type'ZK54'were studied during fruit development.The results showed that diameter(FD),lumen diameter(FLD),pulp thickness(PT),fresh weight(FFW)and fresh weight(FDW)of fruit in'LX1-3'were all higher than those in'ZK54'at 17 days after flowering(DAF).The contents of cell wall components and related enzyme activities were different among cultivars.the content of water-soluble pectin in'LX1-3'was higher than that of'ZK54',and it was significantly positively correlated with PT,FFW,FDW.The contents of hemicellulose(HCE)and cellulose(CE)in'LX1-3'were higher than those in'ZK54'at 17-23 DAF.The activities of β-Gal and β-Xyl of both cultivars at 3 DAF were higher than those at the other three stages.The variation trend of PG,β-Gal and pectinase activities was consistent with that of ionic pectin and covalent pectin.The activities of β-Gal,β-Xyl and cellulase had(extremely)significantly negatively correlated with 5 growth traits,as well as PG with FD,FLD and PT.Therefore,cell wall components and enzyme activities were closely related to fruit development.β-Xyl and β-Gal played major roles in early fruit development,while HCE and CE had great influence on middle and later fruit developments.