In order to understand the chemical constituents of Dendrobium hercoglossum,fourteen compounds were isolated from the aerial parts of D.hercoglossum by using various column chromatography with silica gel,sephadex LH-20,and semi-preparative HPLC.Based on spectroscopic data,their structures were identified as 3,4,5-trimethoxyphenol(1),3-hydroxy-1-(4-hydroxy-3,5-dimethoxyphenyl)-propan-1-one(2),methyl 3-(p-hydro-xyphenyl)propionate(3),justiciresinol(4),ficusal(5),meso-secoisolariciresinol(6),threo-2,3-bis-(4-hydroxy-3-methoxyphenyl)-3-methoxypropanol(7),(+)-pinoresinol(8),aloifol I(9),dendrocandins T(10),3-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-propan-1-one(11),1,3,5-trimethoxybenzene(12),homovanillyl alcohol(13)and(-)-syringaresinol(14).Compounds 1-12,14 were obtained from D.hercoglossum for the first time,and compounds 7,10,and 14 were isolated from Dendrobium species for the first time.The compounds 4,8 and 10 showed significant inhibitory activity,with IC50 of(10.40±0.36),(12.16±0.18)and(9.46±0.78)μmol/L,respectively.
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