Chemical Constituents from Aerial Parts of Dendrobium hercoglossum(Orchidaceae)and Their Biological Activities
In order to understand the chemical constituents of Dendrobium hercoglossum,fourteen compounds were isolated from the aerial parts of D.hercoglossum by using various column chromatography with silica gel,sephadex LH-20,and semi-preparative HPLC.Based on spectroscopic data,their structures were identified as 3,4,5-trimethoxyphenol(1),3-hydroxy-1-(4-hydroxy-3,5-dimethoxyphenyl)-propan-1-one(2),methyl 3-(p-hydro-xyphenyl)propionate(3),justiciresinol(4),ficusal(5),meso-secoisolariciresinol(6),threo-2,3-bis-(4-hydroxy-3-methoxyphenyl)-3-methoxypropanol(7),(+)-pinoresinol(8),aloifol I(9),dendrocandins T(10),3-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-propan-1-one(11),1,3,5-trimethoxybenzene(12),homovanillyl alcohol(13)and(-)-syringaresinol(14).Compounds 1-12,14 were obtained from D.hercoglossum for the first time,and compounds 7,10,and 14 were isolated from Dendrobium species for the first time.The compounds 4,8 and 10 showed significant inhibitory activity,with IC50 of(10.40±0.36),(12.16±0.18)and(9.46±0.78)μmol/L,respectively.
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