One New Picrotoxane-type Sesquiterpene from Dendrobium nobile
In order to study the chemical constituents in butanol fraction of ethanol extract of Dendrobium nobile,column chromatographic techniques including silica gel,Sephadex LH-20,revised silica gel and HPLC were used to separate the compounds,and spectroscopic techniques including NMR and MS were implied to determine the structures.Totally 3 compounds were isolated,and their structures were identified as 2,11-epoxy-11,13-dihydro-xypicrotoxano-3(15)-lactone(1),2,4,6-trimethoxyphenol-1-O-β-D-glycoside(2),3-methylbutan-1-ol β-D-gluco-pyranoside(3).Compound 1 was a new picrotoxane-type sesquiterpene,which is one of the representative components in D.nobile.However,none of the compounds showed α-glucosidase and tyrosinase inhibitory activity,none of them showed activity,and compound 1 show no neuroprotective activity either.
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