In order to understand the chemical composition of Ainsliaea glabra,ten compounds were isolated from petroleum ether extraction fraction of 90% ethanol extract by silica gel,sephadex LH-20 gel column chromatography,semi-preparative high-performance liquid chromatography.Based on spectral data,their structures were identified as pinerenol diisovalerate(1),3β-hydroxy-11α,13-dihydro-costunolide(2),matricarin(3),taraxasteryl acetate(4),betulyl alcohol(5),27-hydroxyolean-12-en-28-oic acid(6),morolic acid acetate(7),(-)-loliolide(8),butyl benzoate(9),and E-phytenal(10).Compound 1 was a new structural compound.Compounds 3 and 7 were isolated from Ainsliaea genus for the first time.Compounds 2-7 and 9 were first reported in the A.glabra.The results of antibacterial activity test showed that compounds 1,2 and 8 had certain inhibitory effects on Staphylococcus aureus with MIC values of 31.2,25.0,and 21.8 μg/mL,and compounds 1 and 3 had potential inhibitory effect on Candida albicans with MIC values of 1.9 and 3.9 μg/mL,respectively.
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