Chemical Constituents from Petroleum Ether Fractions of Ainsliaea glabra and Antibacterial Activities
In order to understand the chemical composition of Ainsliaea glabra,ten compounds were isolated from petroleum ether extraction fraction of 90% ethanol extract by silica gel,sephadex LH-20 gel column chromatography,semi-preparative high-performance liquid chromatography.Based on spectral data,their structures were identified as pinerenol diisovalerate(1),3β-hydroxy-11α,13-dihydro-costunolide(2),matricarin(3),taraxasteryl acetate(4),betulyl alcohol(5),27-hydroxyolean-12-en-28-oic acid(6),morolic acid acetate(7),(-)-loliolide(8),butyl benzoate(9),and E-phytenal(10).Compound 1 was a new structural compound.Compounds 3 and 7 were isolated from Ainsliaea genus for the first time.Compounds 2-7 and 9 were first reported in the A.glabra.The results of antibacterial activity test showed that compounds 1,2 and 8 had certain inhibitory effects on Staphylococcus aureus with MIC values of 31.2,25.0,and 21.8 μg/mL,and compounds 1 and 3 had potential inhibitory effect on Candida albicans with MIC values of 1.9 and 3.9 μg/mL,respectively.
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