摘要
背景 糖尿病痛苦在青少年1型糖尿病患者中高发,给患者带来诸多不良影响.然而,目前关于青少年1型糖尿病患者糖尿病痛苦的相关因素尚不明确.目的 通过Meta分析探索青少年1型糖尿病患者糖尿病痛苦的相关因素,为预防和改善青少年1型糖尿病患者糖尿病痛苦提供参考.方法 于2022年12月1日,计算机检索PubMed、Cochrane Library、Web of Science、Embase、中国知网、万方、维普和中国生物医学文献数据库,系统收集青少年1型糖尿病患者糖尿病痛苦的相关文献,采用美国卫生保健质量和研究机构(AHRQ)推荐的横断面研究质量评价标准和纽卡斯尔-渥太华量表(NOS)分别对横断面研究和队列研究进行质量评价.采用RevMan 5.3进行Meta分析.结果 共纳入22篇文献,包含 6 442例青少年1型糖尿病患者.青少年1型糖尿病患者糖尿病痛苦与年龄(r=0.094,95%CI:0.042～0.145)、糖化血红蛋白(HbA1c)(r=0.291,95%CI:0.248～0.335)、特质焦虑(r=0.585,95%CI:0.526～0.639)、抑郁症状(r=0.635,95%CI:0.590～0.676)、心理韧性(r=-0.410,95%CI:-0.528～-0.276)、父母的糖尿病痛苦(r=0.462,95%CI:0.421～0.501)相关.结论 青少年1型糖尿病患者糖尿病痛苦与多种因素相关,包括年龄、HbA1c、特质焦虑、抑郁症状、心理韧性以及父母的糖尿病痛苦.
Abstract
Background Diabetes distress is highly prevalent and has adverse impacts in adolescent patients with type 1 diabetes.However,the related factors of diabetes distress in adolescents with type 1 diabetes are not clear.Objective To identify the factors associated with diabetes distress in adolescents with type 1 diabetes using Meta-analysis,and to provide a scientific evidence for effective prevention and improvement of diabetes distress in adolescents with type 1 diabetes.Methods On December 1,2022,a computerized search was conducted on databases including PubMed,Cochrane Library,Web of Science,Embase,CNKI,Wanfang Data,VIP and China Biomedical Literature Database,and studies relevant to diabetes distress in adolescents with type 1 diabetes were systematically included.Quality assessment of cross-sectional and cohort studies was carried out using criteria defined by the Agency for Healthcare Research and Quality(AHRQ)and Newcastle-Ottawa Scale(NOS).Then the included studies were pooled in a Meta-analysis using Revman 5.3.Results A total of 22 studies were included,involving 6 442 adolescents with type 1 diabetes.Meta-analysis denoted that the occurrence of diabetes distress among adolescents with type 1 diabetes was correlated with age(r=0.094,95％CI:0.042～0.145),HbA1c(r=0.291,95％CI:0.248～0.335),trait anxiety(r=0.585,95％CI:0.526～0.639),depressive symptoms(r=0.635,95％CI:0.590～0.676),resilience(r=-0.410,95％CI:-0.528～-0.276)and parents'diabetes distress(r=0.462,95％CI:0.421～0.501).Conclusion Factors including age,HbA1c,trait anxiety,depressive symptoms,resilience and parents'diabetes distress are correlated with diabetes distress in adolescents with type 1 diabetes.
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