Research on the Prevention of Hyperuricemia by Citrus Peel Based on Bionetwork
It was elucidated the substance basis and mechanism of action in the treatment of hyperuricemia of citrus peel.The inhibitory effect of citrus peel on xanthine oxidase was determined in vitro to evaluate its preventive effect on hyperuricemia.It were used to predict the material basis and potential mechanism of citrus peel in the treatment of hyperuricemia by network pharmacology,and verified the results by molecular docking.The xanthine oxidase was inhibited by several citrus peel and showed a dose-effect relationship in the linear range.The prediction results of network pharmacology and molecular docking technology showed that naringin and hesperidin are the main active components,which may inhibit hyperuricemia through lipid metabolism and vascular function.The citrus peel of rutaceae can be used in the health industry to prevent hyperuricemia.
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