Study on the Intervention Effect of Momordica charantia Saponins on Acute Alcoholic Liver Injury in Mice
To explore the intervention effect of total saponins from Momordica charantia on acute alcoholic liver injury in mice.Sixty healthy Kunming mice were randomly divided into 6 groups,10 in each group.Blank group,model group,positive control group,bitter melon saponins high dose group,bitter melon saponins middle dose group and bitter melon saponins low dose group.In addition to the blank group,other groups were given liquor at 9:00 am for 10 consecutive days to establish acute alcoholic liver injury model.At 2:00 pm,except the model group and the blank group were given saline,other groups were given intervention treatment.After 12 h of the last administration,the alcohol status of each group was compared.The liver was weighed,the liver coefficient was calculated,the liver tissue sections were taken for pathological analysis,and the contents of biochemical indexes in serum and liver of mice were measured.The results showed that the total saponins of bitter melon could significantly increase the liver index.In the model group,the levels of AST and ALT in serum and the content of MDA in liver were decreased,the content of GSH in liver was increased,the activities of SOD and CAT in liver were enhanced,and the degeneration of hepatocyte granules was improved to varying degrees.Momordica charantia total saponins can effectively alleviate acute alcoholic liver injury in mice induced by liquor,and its mechanism may be related to the reduction of free radicals and lipid peroxides on liver cell damage.
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