Study on Optimal Formulation of Cistanche Rose Slices by Response Surface Method
The Box-Behnken multiple regression model was constructed to optimize the formulation of Cistanche rose tablets by single factor experiment and response surface test to explore the effects of different amounts of raw materials(extract mixture),ethanol and excipients on the texture and molding rate of the tablets,as well as to identify and determine the main components of the final product.The results showed that the optimal formulation of Cistanche rose slice is as follows:101.60 g of plant extracts additions such as Cistanche and rose,21.90 g of microcrystalline cellulose,15.25 mL of 90%ethanol,6.70 g of sodium carboxymethyl starch,and 2.68 g of magnesium stearate,and the Cistanche rose slices produced according to this formulation were intact,with a glossy and clean surface,good compressibility,and a more homogeneous color,and the value of the forming rate was 97.4%.The results of thin-layer chromatographic identification of the tablets were good;the mean values of the marker components were 2.236 mg/g of echinacoside,and 0.460 mg/g of verbascoside.The results of this study could provide a theoretical reference for the development and standardized production of functional foods.
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