首页|硬骨鱼类虹彩细胞的研究进展

硬骨鱼类虹彩细胞的研究进展

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  • 国家科技期刊平台
  • NETL
  • NSTL
  • 万方数据
  • 维普
虹彩细胞是硬骨鱼中一类常见的色素细胞，含有大量的虹彩小体，其内含有由鸟嘌呤晶体构成的高折射率的反射小板，反射小板与低折射率的细胞质交替排列形成交替层的结构，光被交替层反射后通过多层薄膜干涉，使细胞呈现出彩虹般的颜色。虹彩细胞能在激素、交感神经系统或外界环境刺激的作用下通过改变反射小板的间距来实现颜色的变化。鸟嘌呤是虹彩细胞呈色和颜色变化的基础，其合成途径已被详细解析。虹彩细胞由多能的神经嵴细胞分化而来，从神经嵴细胞分化为成熟的虹彩细胞的谱系特化过程受到多个基因的调控，目前已在模式生物斑马鱼中发现了一些关键基因，并通过对这些基因间相互作用的研究初步解析了控制虹彩细胞特化的核心基因调控网络，同时也发现了其他影响虹彩细胞特化、分化及存活的基因和信号通路。本文综述了硬骨鱼类虹彩细胞呈色及颜色变化的机制、鸟嘌呤合成途径及调控基因以及影响虹彩细胞发育和存活的基因和信号通路的研究进展，并对未来的研究方向进行了展望，期望能对虹彩细胞有更深入的认识，并为研究虹彩细胞发育过程的基因调控提供参考。
Research advances of iridophores in Teleosts
The iridophore is a kind of common pigment cell in teleosts.It contains a large number of iridosomes,which contain reflecting platelets with high refractive index composed of guanine crystals.The reflecting platelets and the cytoplasm with low refractive index are alternately arranged to form alternating layers.After light is reflec-ted by the alternating layers,the iridophores show an iridescent color through multilayer thin-film interference.Iridophores achieve color change by changing the distances between each of the reflecting platelets under the stim-ulation of hormones,sympathetic nervous system or external environment factors.Guanine is the basis for the col-oration and color changes of iridophores,and its biosynthesis pathway has been analyzed in detail.Iridophores are differentiated from multipotent neural crest cells.The lineage specialization process of differentiation from neural crest cells to mature iridophores requires multiple genes.At present,some key genes have been found in the model organism,zebrafish,and the core gene regulatory network governing iridophore specification has been preliminar-ily analyzed through studying the interactions among those genes.At the same time,other genes and signaling pathways affecting the specialization,differentiation and survival of iridophores have also been found.This manuscript reviews advances of studies in the mechanism of coloration and color change of iridophores,the path-way and genes involved in guanine biosynthesis,as well as genes and signaling pathways affecting the develop-ment and survival of iridophores in teleosts.Prospects for future research directions are also provided.It is aimed at a deeper understanding of iridophores and providing a reference for studying gene regulation during iridophore development.

Teleostsmodel fishesiridophoreguanine biosynthesiscolor changelineage specificationgene regulationsignaling pathway

田浚杉、唐雨馨、王晨旭、王德寿

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西南大学生命科学学院,淡水鱼类资源与生殖发育教育部重点实验室,重庆 400715

硬骨鱼类 模式鱼类 虹彩细胞 鸟嘌呤合成 颜色变化 谱系特化 基因调控 信号通路

国家自然科学基金国家自然科学基金重庆市水产科技创新联盟项目(2023)国家级大学生创新创业训练计划

3187255631861123001202210635098

2024

10.11964/jfc.20230213903

水产学报
中国水产学会

水产学报

CSTPCD北大核心
影响因子：1.148
ISSN：1000-0615
年,卷(期)：2024.48(1)
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