Objective To investigate clinical effects of different surgical procedures for spinal osteoblastoma.Methods From January 2016 to January 2022,16 patients with osteoblastoma of spine were treated in our hospital,including 7 males and 9 females,aged 12~61 years(mean 24.9 years).The lesions were located in cervical vertebrae(2 cases),thoracic vertebrae(10 ca-ses)and lumbar vertebrae(4 cases).The main symptoms were local pain,which was not clear day and night.2 cases with neurolog-ical symptoms were found in thoracic spine,Frankel C 1 case and Frankel D 1 case.According to Enneking staging,10 cases were stage Ⅱ and 6 cases were stage Ⅲ.The operative methods were extended resection in stage Ⅱ and total spondylectomy in stageⅢ.Results All patients were followed up for 12~60 months(mean 25.8 months).Postoperative wound infection and cerebrospi-nal fluid leakage were not found.Neurological symptoms were not aggravated.For neurological function,Frankel D grade was im-proved to Frankel E grade in one case,and Frankel C grade was improved to Frankel D grade in one case.No recurrence was found in all cases after follow-up.Conclusion Osteoblastoma of spine should be treated as an intermediate tumor(locally infiltrating type),and surgical treatment to prevent postoperative tumor recurrence is key.The extended resection of tumor in Enneking stageⅡ and total spondylectomy in Enneking stage Ⅲ could prevent tumor recurrence and obtain satisfactory clinical results.