摘要
目的 探讨注意缺陷多动障碍(ADHD)患儿血清神经元特异性烯醇化酶(NSE)和中枢神经特异性蛋白(S100β)表达与其社会功能的关系.方法 选取2022 年2 月至2023 年3 月我院收治的136 例ADHD患儿为ADHD组,选取同时期在我院体检的136 例健康儿童为健康组.采用酶联免疫吸附试验(ELISA)测定两组儿童血清NSE、S100β表达水平.采用Weiss功能缺陷量表父母版(WFIRS-P)评价两组儿童的社会功能.采用Spearman相关性分析ADHD患儿血清NSE、S100β表达水平与WFIRS-P评分之间的相关性.结果 ADHD组患儿血清NSE、S100β表达水平均高于健康组(P<0.05).ADHD组儿童WFIRS-P量表家庭、学校/学习、自我管理、社会活动、生活技能、冒险活动评分均高于健康组(P<0.05).Spearman相关性分析显示,ADHD患儿血清NSE水平与WFIRS-P量表家庭、学校/学习、自我管理、社会活动、生活技能、冒险活动6 个维度的评分均呈明显正相关(rs=0.531,0.560,0.516,0.402,0.591,0.584,均P<0.001);血清S100β水平与WFIRS-P量表家庭、学校/学习、自我管理、社会活动、生活技能、冒险活动6 个维度的评分均呈明显正相关(rs=0.573,0.555,0.418,0.457,0.495,0.546,均P<0.001).结论 ADHD患儿血清NSE、S100β水平明显上调,二者均与社会功能明显相关.
Abstract
Objective To explore the relationship between the expression of serum neuron specific enolase(NSE)and central nerve system specific protein(S100β)in children with attention deficit hyperactivity disorder(ADHD)and their social func-tion.Methods A total of 136 children with ADHD admitted to our hospital from February 2022 to March 2023 were selected as the ADHD group,and 136 healthy children who underwent physical examination at the same time were collected as the health group.Enzyme linked immunosorbent assay(ELISA)was applied to determine the expression levels of serum NSE and S100β of children in two groups.The Weiss Functional Impairment Rating Scale-Parent Version(WFIRS-P)was applied to evaluate the so-cial function of children in two groups.Spearman correlation was applied to analyze the correlation between serum NSE,S100β ex-pression levels and WFIRS-P score in children with ADHD.Results The expression levels of serum NSE and S100β in the ADHD group were higher than those in the healthy group(P<0.05).The scores of family,school/learning,self-management,social activities,life skills,and adventure activities on the WFIRS-P scale for children in the ADHD group were higher than those in the healthy group(P<0.05).Spearman correlation analysis showed that the serum NSE level of ADHD patients was obviously positively correlated with the scores of six dimensions of the WFIRS-P scale:family,school/learning,self-management,social ac-tivities,life skills,and adventure activities(rs=0.531,0.560,0.516,0.402,0.591,0.584,all P<0.001);the serum S100β level was obviously positively correlated with the scores of six dimensions of the WFIRS-P scale,including family,school/learning,self-management,social activities,life skills,and adventure activities(rs=0.573,0.555,0.418,0.457,0.495,0.546,all P<0.001).Conclusion The serum levels of NSE and S100β in children with ADHD are obviously up-regulated,and both of them are obviously related to social function.
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