Objective To investigate the correlation between the expression of serum histone deacetylase 6(HDAC6)and brain derived neurotrophic factor(BDNF)in patients with vascular dementia(VD)and their cognitive function and progno-sis.Methods A total of 126 patients with VD who underwent treatment in our hospital from October 2020 to December 2022 were collected as the study subjects(VD group),another 100 patients with ischemic brain stroke who were treated in our hospital at the same period but did not develop VD were collected as the control group.ELISA method was applied to measure the serum levels of BDNF and HDAC6 in all subjects;Montreal Cognitive Function Scale(MoCA)was applied to assess cognitive function;the serum levels of BDNF and HDAC6 were compared among patients with different degrees of illness and prognosis;Pearson cor-relation was applied to analyze the relationship between serum BDNF,HDAC6 levels and MoCA score in VD patients;Receiver operating characteristic(ROC)curve was applied to analyze the predictive value of serum BDNF and HDAC6 levels for grade Ⅲprognostic dysfunction.Results Compared with the control group,the serum BDNF level in the VD group was obviously lower(P＜0.05),while the HDAC6 level was obviously higher(P＜0.05).Pearson correlation analysis showed that serum BDNF was obviously positively correlated with MoCA score(r=0.488,P＜0.05),while serum HDAC6 was obviously negatively correlated with MoCA score(r=-0.490,P＜0.05).Compared with the grade Ⅰ group,the serum BDNF level in the grade Ⅱ and Ⅲgroups were obviously lower(P＜0.05),and the grade Ⅲ group was obviously lower than the grade Ⅱ group(P＜0.05),the HDAC6 level was obviously higher(P＜0.05),and the grade Ⅲ group was obviously higher than the grade Ⅱ group(P＜0.05).ROC curve results showed that the area under the curve(AUC)of BDNF and HDAC6 in predicting grade Ⅲ prognostic dysfunc-tion was 0.906(95％CI 0.848～0.965)and 0.905(95％CI 0.847～0.964),respectively,with sensitivity of 95.5％and 95.5％,specificity of 74.3％and 70.5％,respectively.The AUC of the two combination for predicting grade Ⅲ prognostic dys-function was 0.977(95％CI 0.940～1.000),with a sensitivity of 90.9％and a specificity of 89.9％.Conclusion The serum BDNF level in VD patients is obviously reduced,while HDAC6 level is obviously increased.Both are closely related to cognitive dysfunction and prognosis,and can provide some reference for clinical diagnosis and treatment.
维普
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