Objective To analyse the clinical and laboratory characteristics and explore the possible risk factors for anky-losing spondylitis(AS)with hyperuricemia(HUA).Methods Clinical data of AS patients treated in our hospital from January 2014 to June 2022 were collected and divided into high uric acid(HUA)group and non-high uric acid(NHUA)group,and the differences between clinical and laboratory indicators between the two groups were compared.Results ①402 AS patients were e-ventually included in this cross-sectional study,including 93 in HUA group and 309 in NHUA group;HUA was significantly more frequent in men than in women(28.62％vs.8.92％,P＜0.05).②Age and duration of AS in HUA group were significantly smaller than NHUA group(P＜0.05).There were no significant differences in AS family history,HLA-B27 positive rate,Bady Mass Index(BMI),smoking history,extra-joint symptoms,and peripheral arthritis(P＞0.05).③ ESR、PLT、GR％、eGFR、BASDAI、BASFI score were significantly lower than NHUA(all P＜0.05),while hepatobiliary metabolism,CysC and Crea were significantly higher than NHUA(P＜0.05).④sUA levels were negatively correlated with ESR,GR％,BASDAI,and BASFI(P＜0.05).⑤Logistic Regression analysis found that men,high Crea and low eGFR were risk factors for HUA in AS patients,while advanced age and high ESR might be protective factors for HUA in AS patients.Conclusion The incidence of AS with HUA is high,especially in male and AS patients with younger age,requiring regular monitoring of sUA;AS patients with HUA show relatively low disease activity,and sUA can self-protect inflammation through oxidative stress,but the specific mechanism needs further study.
维普
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