Objective To observe changes of brain functional connectivity(FC)in patients with benign paroxysmal posi-tional vertigo(BPPV)before and after canalith repositioning procedure(CRP),and to analyze the correlation between FC and ver-tigo degree(THI)in patients with BPPV,so as to explore the central mechanism of BPPV from the perspective of morphology.Methods Functional near-infrared imaging(fNIRS)was used to test the changes of FC in patients with BPPV before and after CRP treatment,and the correlation between FC and DHI scale scores in patients with BPPV was analyzed.Results The FC of BPPV group was lower than that of normal control group before and after CRP treatment.In BPPV group,DHI score was negatively corre-lated with FC(P＜0.01).After CRP treatment,the FC of visual cortex V2+V3,visual cortex V1 and somatosensory cortex in BP-PV patients were higher than those before treatment(P＜0.01).Conclusion Compared with normal control group,the whole brain FC of patients with BPPV decreases,mainly involving the prefrontal cortex,visual cortex and somatosensory cortex.After CRP treatment,the FC of BPPV patients increases,but does not reach the normal level,which may be related to the persistent dizziness after CRP treatment in BPPV patients.The lower the FC of the brain network in BPPV patients,the more severe the vertigo.
维普
万方数据