Effect of Early Sacubactril Valsartan on Cardiac Function and Left Ventricular Remodeling After Emergency PCI in Patients with Heart Failure After STEMI
Effect of Early Sacubactril Valsartan on Cardiac Function and Left Ventricular Remodeling After Emergency PCI in Patients with Heart Failure After STEMI
Objective To explore the effects of early application of Sacubactril valsartan on cardiac function and left ven-tricular remodeling after emergency PCI in patients with heart failure after STEMI.Methods A total of 130 STEMI patients with heart failure who received PCI in the Department of Cardiovascular of our Hospital from October 2021 to April 2022 were selected and divided into control group and observation group according to random number table method,with 65 cases in each group.With-in 24 h after PCI,the control group was treated with enalapril tablets,and the observation group was treated with Sacubattril valsar-tan.The serum N-terminal B-type brain natriuretic peptide(NT-proBNP)levels were observed immediately after PCI and at 4 and 24 weeks after PCI.Left ventricular end-systolic volume(LVESV),left ventricular ejection fraction(LVEF),left ventricular end-diastolic volume(LVEDV)and other cardiac function indicators.6-minute walking test at 4 and 24 weeks after surgery.Two groups of adverse cardiovascular events(MACE);Prognosis of death,reinfarction,outpatient heart failure or hospitalization for heart failure,malignant arrhythmia or stroke;An adverse reaction.Results Serum NT-proBNP in the observation group was lower than that in the control group at 4 and 24 weeks after surgery(P＜0.05).At 4 and 24 weeks after operation,LVEF in observation group was higher than that in control group(P＜0.05),LVESV and LVEDV in observation group were lower than that in control group(P＜0.05).The 6-minute walking test distance of the observation group increased at 4 weeks and 24 weeks after surgery compared with the control group(P＜0.05).The incidence of heart failure or heart failure hospitalization,malignant arrhythmia and death in observation group was lower than that in control group(P＜0.05).The incidence of reinfarction,stroke and the inci-dence of adverse reactions during treatment were not different between the two groups(P＞0.05).Conclusions Sakubactril val-sartan can improve left ventricular systolic function,inhibit left ventricular remodeling and reduce NT-proBNP level in STEMI pa-tients with heart failure after PCI.
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