Objective To compare and analyze clinical effects of suprapatellar and infrapatellar approach in the treatmen of multiple tibial fractures,and to explore application value of suprapatellar approach in treatment of multiple tibial fractures.Meth-ods From May 2020 to March 2023,clinical data of 41 patients with multiple tibial fractures treated by suprapatellar and infrapa-tellar approach intramedullary nail in our hospital were retrospectively analyzed.Among which 22 patients recived suprapatellar ap-proach(group SP),and 19 patients recived the infrapatellar approach(group IP).Surgical time,intraoperative bleeding volume,number of fluoroscopy sessions,incidence of postoperative knee anterior pain,fracture healing time and and incidence of postopera-tive complications were recorded and compared.At the last follow-up,clinical efficacy was evaluated using the Johne Wruhs score.Results All patints were followed up,group SP was followed up with an anverage of(16.55±9.24)months and group IP was followed up with an anverage of(17.23±10.06)months.Group SP was significantly fewer than group IP in terms of surgical time,intraoperative bleeding volume,number of fluoroscopy sessions(P<0.05).Group SP(9.09%)was significantly fewer than group IP(42.11%)in terms of incidence of postoperative complications(P<0.05).There were no significant differe in fracture healing time between group SP(11.2±0.61)weeks and group IP(12.33±0.42)weeks(P>0.05).There were no significant differe in Johne Wruhs score between group SP(excellent rate:95.24%)and group IP(excellent rate:94.73%)(P>0.05).Conclusion Both the suprapatellar and infrapatellar approaches have shown good clinical efficacy in the treatment of multiple tib-ial fractures.However,the suprapatellar approach is superior to the infrapatellar approach in terms of surgical operation and patient comfort,and further observation is needed for its long-term effects.