Objective To study effects and safety of misoprostol vaginal tablets and dinoprostone suppositories for term pregnancy in inducing labor.Methods Term pregnant women with cervical immaturity and indications for labor induction in our hospital were selected and admitted between June 2021 to February 2023 in our hospital.Among them,243 cases were induced with misoprostol vaginal tablets(new dosage forms,25 μg),156 cases were induced with dinoprostone suppositories(10 mg),intravagi-nal administration of drugs.The cervical maturity after drug administration,method of delivery and complications of delivery were compared retrospectively.Results The comparison of the cervical maturity after drug administration and method of delivery showed no statistical difference(P＞0.05).Compared with two groups,dinoprostone suppositories group had a higher rate of the vaginal delivery at 24 h of drug administration and over frequent contractions than the misoprostol vaginal tablets group(P＜0.01).The misoprostol vaginal tablets group had a higher rate of the vaginal delivery at 24～48 h of drug administration and addi-tional using oxytocin than the dinoprostone suppositories group(P＜0.01).The comparison of the complications of delivery such as postpartum hemorrhage≥500 ml,operative vaginal delivery,urgent production,the rate of neonatal transfer from obstetrics to pe-diatrics and amniotic fluid pollution showed no statistical difference(P＞0.05).Conclusion Misoprostol vaginal tablets and di-noprostone suppositories are comparable in cervical ripening promotion at term pregnancy,method of delivery and the safety of ma-ternal and infant.Misoprostol vaginal tablets has a relatively mild effect,and has a higher rate of additional using oxytocin,but is less likely to cause over frequent contractions,can be promoted for clinical using.
关键词
米索前列醇片/地诺前列酮栓/足月妊娠/引产
Key words
misoprostol vaginal tablets/dinoprostone suppositories/full-term pregnancy/induction of labor
维普
万方数据