Efficacy and Safety of External Diaphragm Pacing in the Treatment of Acute COPD:A Meta Analysis
肖洋 1杨潇 1李雪 2张雨尧 2雷宇 1王永生1
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作者信息
1. 成都市中西医结合医院,四川成都 610041
2. 成都中医药大学附属医院,四川成都 610072
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摘要
目的 运用Meta分析系统评价体外膈肌起搏对慢性阻塞性肺疾病急性加重期(AECOPD)患者的疗效与安全性,为临床应用提供循证依据.方法 计算机检索万方数字化期刊全文数据库、中国期刊全文数据库、维普中文科技期刊数据库、PubMed、Web of Science、Embase、Cochrane Library、中国生物医学文献等数据库.检索时限为建库至2023年7月1日,收集体外膈肌起搏对AECOPD的随机对照试验,由两位研究人员独立进行文献筛选、数据提取和研究偏倚风险评价,使用RevMan5.3软件进行Meta分析.结果 最终纳入文献15篇,共1263例患者,Meta分析提示:采用体外膈肌起搏治疗AECOPD在提高PaO2、6 min步行距离,降低PCO2,提高FEV1、FVC、FEV1/FVC等肺功能指标,差异有统计学意义.结论 Meta分析结果表明,体外膈肌起搏可以改善AECOPD患者肺功能,提高PaO2,降低PCO2,提高患者运动能力.
Abstract
Objective To evaluate the efficacy and safety of external diaphragm pacing in patients with AECOPD by Meta analysis system,so as to provide evidence-based basis for clinical application.Methods Wanfang digital periodical full-text data-base,Chinese periodical full-text database,VIP Chinese sci-tech periodical database,PubMed,Web of Science,Embase,Cochrane Library,Chinese biomedical literature database were searched by computer.The search period was from the establishment of the da-tabase to July 1,2023.Randomized controlled trials of external diaphragm pacing on AECOPD were collected.Literature screening,data extraction and study bias risk assessment were conducted independently by two researchers,and RevMan5.3 software was used for Meta analysis.Results Total 1263 patients with 15 articles were included.Meta analysis showed that external diaphragm pa-cing could increase the indexes including PaO2,6min walking distance,reduce PCO2,and improve the pulmonary function indexes such as FEV1,FVC and FEV1/FVC.The differences were statistically significant.Conclusion Meta analysis shows that external diaphragm pacing can improve pulmonary function,increase PaO2,decrease PCO2 and improve the exercise ability in patients with AECOPD.
关键词
体外膈肌起搏/慢性阻塞性肺疾病急性期/肺功能/生活质量
Key words
extracorporeal diaphragm pacing/acute phase of COPD/pulmonary function/quality of life
维普
万方数据