Objective To compare hemostatic efficacy of tranexamic acid(TXA)and gelatin in the perioperative man-agement of bone and soft tissue tumor surgery,aiming to provide a more economical and more effective hemostatic option for pa-tients.Methods A controlled trial was conducted,enrolling 76 patients undergoing bone and soft tissue tumor surgery between Oc-tober 2019 and January 2022.Based on intraoperative hemostatic interventions,patients were divided into TXA group(n=50,re-ceived intravenous infusion of 1 g tranexamic acid 30 minutes preoperatively)and gelatin group(n=26,local application of ap-proximately 2 ml gelatin at bleeding sites during surgery).Primary outcomes included hemoglobin,hematocrit,and platelet count.Secondary outcomes encompassed inflammatory markers,coagulation profiles,fibrinolytic markers,estimated intraoperative blood loss,and hospitalization duration.Results On postoperative day 1,hemoglobin were(118.94±16.79)g/L in TXA group and(116.46±16.81)g/L in gelatin group,with no statistically significant difference(P=0.984).The cost of hemostatic drugs was lower in the tranexamic acid group than in the gelatin group(P＜0.05).No significant differences were observed in other primary or secondary outcomes(all P＞0.05).Conclusion Tranexamic acid and gelatin demonstrated comparable hemostatic efficacy in the perioperative period of bone and soft tissue tumor surgery.However,considering its lower cost,tranexamic acid may represent a more cost-effective hemostatic option for patients undergoing bone tumor surgery.
关键词
骨软组织肿瘤/氨甲环酸/明胶/止血/围术期
Key words
bone soft tissue tumor/tranexamic acid/gelatin/hemostasis/perioperative period
维普
万方数据