hs-CRP、Fg、ALP、WBC水平对骨伤术后感染的诊断分析
Analysis of Hs-CRP,Fg,ALP and WBC Levels in Diagnosis of Postoperative Infection of Bone Injury
胡高强1
作者信息
- 1. 泸州市泸县人民医院,四川 泸州 646000
- 折叠
摘要
目的:分析超敏C反应蛋白(hypersensitive C-reactive protein,hs-CRP)、纤维蛋白原(Fibrinogen,Fg)、碱性磷酸酶(Alkaline phosphatase,ALP)、白细胞计数(White blood cell count,WBC)水平对骨伤术后感染的诊断价值.方法:选择我院在 2021年 7月—2022年 7月期间收治的骨伤术后发生感染的患者 48例为观察组,另选择同时期进行骨伤手术但未发生感染的患者 49例为对照组,对比 2组患者血清hs-CRP、Fg、ALP、WBC水平,对比感染前后观察组hs-CRP、Fg、ALP、WBC水平,并计算血清因子的诊断价值.结果:感染与时间对hs-CRP、Fg、ALP及WBC水平具有交互作用,差异有统计学意义(P<0.05).治疗完成首次复查时,观察组血清hs-CRP、Fg、ALP、WBC水平较治疗前相比有所下降,差异有统计学意义(P<0.05).ROC曲线分析结果显示,hs-CRP、Fg、ALP以及WBC诊断骨伤术后患者感染的曲线下面积(Area under curve,AUC)分别为 0.964、0.929、0.913、0.798.其中,hs-CRP的AUC最大,为 0.964,最佳临界值为3.81,灵敏度为 87.50%、特异度为 93.70%,但ROC结果显示,WBC及Fg的特异度更高,均为 97.90%,因此研究认为结合hs-CRP、Fg、ALP及WBC四项指标进行联合检测的效果更佳.结论:针对骨伤手术术后感染患者实施联合hs-CRP、Fg、ALP、WBC指标检测的诊断价值更高,且对患者后续的疗效观察具有较好的临床应用价值,值得推广.
Abstract
Objective:Hypersensitive C-reactive protein(hs-CRP),Fibrinogen(Fg),Alkaline phosphatase(ALP)and White blood cell count(WBC)in the diagnosis of infection were analyzed after bone injury surgery.Methods:48 patients with infection after bone injury surgery admitted to our hospital from July 2021 to July 2022 were selected as the observation group,and 49 patients who underwent bone injury surgery without infection during the same period were selected as the control group.The serum levels of hs-CRP,Fg,ALP and WBC were compared between the two groups.The levels of hs-CRP,Fg,ALP and WBC in the observation group before and after infection were compared,and the diagnostic value of serum factors was calculated.Results:Infection and time had an interaction effect on the levels of hs-CRP,Fg,ALP and WBC,and the difference was statistically significant(P<0.05).After the first reexamination,the levels of hs-CRP,Fg,ALP and WBC in the observation group were lower than those before treatment,and the differences were statistically significant(P<0.05).ROC curve analysis showed that the Area under curve(AUC)of hs-CRP,Fg,ALP and WBC in the diagnosis of infection in patients with bone injury after surgery was 0.964,0.929,0.913 and 0.798,respectively.Among them,the AUC of hs-CRP was the largest(0.964),the best cut-off value was 3.81,the sensitivity was 87.50%,and the specificity was 93.70%.The ROC results showed that the specificity of WBC and Fg was higher 97.90%.Therefore,the study suggests that the combined detection of hs-CRP,Fg,ALP and WBC is better.Conclusion:For patients with infection after bone injury surgery,the combined detection of hs-CRP,Fg,ALP and WBC has higher diagnostic value,and has good clinical application value for the follow-up observation of the curative effect of patients,which is worthy of promotion.
关键词
感染/超敏C反应蛋白/纤维蛋白原/碱性磷酸酶/诊断价值Key words
Infection/High-sensitivity C-reactive protein/Fibrinogen/Alkaline phosphatase/Diagnostic value引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
万方数据