抗骨质疏松联合方案对PVP患者骨量的影响
Effect of Anti-Osteoporosis Combination Regimen on Bone Mass in PVP Patients
魏健1
作者信息
- 1. 山西医科大学附属汾阳医院骨一科,山西 汾阳 032200
- 折叠
摘要
目的:严重骨质疏松致椎体骨折椎体强化术(PVP)后,使用抗骨质疏松治疗(CVPC方案),观察骨指标的变化情况,研究抗骨质疏松治疗在PVP术后的作用.方法:本研究纳入 36例骨质疏松性椎体骨折(OVCF)患者为研究对象,均行PVP治疗.根据患者是否接受CVPC治疗分为治疗组 20例、对照组 16例,研究 2组指定时间段的骨密度值(BMD)、骨转化物(BTMs)水平,结合疼痛视觉模拟评分(VAS)评价疗效.结果:治疗后 3个月,2 组骨密度T值均高于治疗后即刻,且治疗组高于对照组,但差异无统计学意义(P＞0.05);治疗后 6、12个月,治疗组骨密度T值均高于治疗后即刻,且治疗组高于对照组,差异有统计学意义(P＜0.05),对照组骨密度T值均高于治疗后即刻,但差异无统计学意义(P＞0.05).治疗后 3个月,2 组I型原胶原氨基端前肽(PINP)、I型胶原交联羧基末端肽(CTX)水平均高于治疗后即刻,且治疗组高于对照组,但差异无统计学意义(P＞0.05);治疗后 6、12个月,治疗组PINP、CTX水平均高于治疗后即刻,且治疗组高于对照组,差异有统计学意义(P＜0.05),对照组PINP、CTX水平均高于治疗后即刻,但差异无统计学意义(P＞0.05).2组术后随访,治疗组再骨折发生率低于对照组,差异有统计学意义(P＜0.05).术前、治疗后即刻、3、6个月,2组VAS评分比较,组间差异无统计学意义(P＞0.05);治疗后12个月,治疗组VAS评分低于对照组,差异有统计学意义(P＜0.05).结论:骨质疏松性椎体骨折PVP治疗后使用CVPC方案,可以改善骨密度,优化骨转化物水平,缓解症状,减少再骨折发生率.
Abstract
Objective:To observe the changes of bone indexes and study the effect of anti-osteoporosis therapy after vertebral augmentation(PVP)for vertebral fracture caused by severe osteoporosis.Methods:36 patients with osteoporotic vertebral fractures(OVCF)were enrolled in this study and treated with PVP.The patients were divided into the treatment group(n=20)and the control group(n=16)according to whether they received CVPC treatment or not.The bone mineral density(BMD)and bone turnover factor(BTMs)levels of the two groups at specified time points were studied,and the efficacy was evaluated combined with visual analogue scale(VAS)score.Results:After 3 months of treatment,the T value of bone mineral density in the two groups was higher than that immediately after treatment,and the treatment group was higher than the control group,but the difference was not statistically significant(P＞0.05).At 6 and 12 months after treatment,the T value of bone mineral density in the treatment group was higher than that immediately after treatment,and the T value in the treatment group was higher than that in the control group,the difference was statistically significant(P＜0.05).The T value of bone mineral density in the control group was higher than that immediately after treatment,but the difference was not statistically significant(P＞0.05).At 3 months after treatment,the levels of procollagen type I amino-terminal propeptide(PINP)and cross-linked carboxy-terminal telopeptide of type I collagen(CTX)in the two groups were higher than those immediately after treatment,and those in the treatment group were higher than those in the control group,but the differences were not statistically significant(P＞0.05).At 6 and 12 months after treatment,the levels of PINP and CTX in the treatment group were higher than those immediately after treatment,and those in the treatment group were higher than those in the control group,the differences were statistically significant(P＜0.05).The levels of PINP and CTX in the control group were higher than those immediately after treatment,but the differences were not statistically significant(P＞0.05).The incidence of re-fracture in the treatment group was lower than that in the control group,and the difference was statistically significant(P＜0.05).There was no significant difference in VAS scores between the two groups before operation,immediately after treatment,3 months and 6 months after treatment(P＞0.05).At 12 months after treatment,the VAS score of the treatment group was lower than that of the control group,and the difference was statistically significant(P＜0.05).Conclusion:CVPC regimen after PVP for osteoporotic vertebral fractures can improve bone mineral density,optimize bone turnover level,relieve symptoms,and reduce the incidence of re-fracture.
关键词
椎体成形术/CVPC方案/骨密度/骨转化物/疼痛视觉模拟评分Key words
Vertebroplasty/CVPC solution/Bone density/Bone conversion/Visual analogue pain score引用本文复制引用
基金项目
山西医科大学附属汾阳医院课题基金资助项目(202001)
出版年
2024
国家科技期刊平台
NSTL
万方数据