摘要
目的:探讨镇痛消风汤联合塞来昔布治疗痛风的疗效分析及对血清尿酸(UA)、载脂蛋白A 1(ApoA 1)水平的影响.方法:选择 2020年 1月—2023年 1月我院收治的 82例急性痛风性关节炎患者为研究对象,随机分为对照组与观察组,观察组(n=42)采用镇痛消风汤联合塞来昔布治疗,对照组(n=40)采用塞来昔布单药治疗,治疗前后采用数字评估法(NRS)评估疼痛,进行中医症候评分,评价临床疗效,并检测血清UA、ApoA 1 水平.结果:治疗前及治疗 3 d后,2组NRS评分比较,差异无统计学意义(P>0.05);治疗 5、7 d后,观察组NRS评分低于对照组,差异有统计学意义(P<0.05).治疗前,2组中医症候评分比较,差异无统计学意义(P>0.05);治疗后,观察组中医症候评分低于对照组,差异有统计学意义(P<0.05).观察组总有效率为 90.48%,高于对照组的 67.50%,差异有统计学意义(P<0.05).治疗前,2 组血清UA、ApoA 1 水平比较,组间差异无统计学意义(P>0.05);治疗后,2组血清UA水平均低于治疗前,且观察组血清UA水平低于对照组,差异有统计学意义(P<0.05);2组血清ApoA 1水平均较治疗前升高,且观察组高于对照组,差异无统计学意义(P>0.05).结论:镇痛消风汤联合塞来昔布治疗急性痛风性关节炎患者,可有效降低UA水平,改善关节症状,提升临床疗效.
Abstract
Objective:To investigate the efficacy of Zhentong Xiaofeng decoction combined with celecoxib in the treatment of gout and its effect on serum uric acid(UA)and apolipoprotein A1(ApoA1)levels.Methods:82 patients with acute gouty arthritis admitted to our hospital from January 2020 to January 2023 were selected as the research objects and were randomly divided into a control group and an observation group.The observation group(n=42)was treated with Zhentong Xiaofeng Decoction combined with celecoxib,and the control group(n=40)was treated with celecoxib alone.Before and after treatment,the pain was evaluated by digital evaluation method(NRS),TCM symptom score was performed,clinical efficacy was evaluated,and serum UA and ApoA 1 levels were detected.Results:Before treatment and 3 days after treatment,there was no significant difference in NRS scores between the two groups(P>0.05);after 5 and 7 days of treatment,the NRS scores of the observation group were lower than those of the control group,and the difference between the two groups was statistically significant(P<0.05).Before treatment,there was no statistically significant difference in TCM syndrome scores between the two groups(P>0.05);after treatment,the TCM syndrome score of the observation group was lower than that of the control group,and the difference was statistically significant(P<0.05).The total effective rate of the observation group was 90.48%,which was higher than 67.50%of the control group,and the difference was statistically significant(P<0.05).Before treatment,there was no significant difference in serum UA and ApoA1 levels between the two groups(P>0.05);after treatment,the serum UA levels of the two groups were lower than those before treatment,and the serum UA level of the observation group was lower than that of the control group,and the difference was statistically significant(P<0.05);the serum ApoA1 levels of the two groups were higher than those before treatment,and the observation group was higher than the control group,the difference was not statistically significant(P>0.05).Conclusion:Zhentong Xiaofeng Decoction combined with celecoxib can effectively reduce UA level,improve joint symptoms,and improve the clinical efficacy in the treatment of patients with acute gouty arthritis.
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