唑来膦酸治疗老年骨质疏松的效果
Effect of Zoledronic Acid in the Treatment of Elderly Osteoporosis
陈素萍1
作者信息
- 1. 建湖县人民医院药剂科,江苏 盐城 224700
- 折叠
摘要
目的:探讨并分析唑来膦酸治疗老年骨质疏松的效果.方法:选择 2021 年 1 月-2022 年2月于建湖县人民医院诊治的 94例骨质疏松患者作为研究对象,随机将患者分为唑来膦酸组与传统组,各47 例.传统组给予常规药物治疗,唑来膦酸组在传统组的基础上给予唑来膦酸治疗,2 组均治疗并观察 4 周.比较 2 组的临床疗效、疼痛与骨代谢变化情况.结果:治疗 4 周后,唑来膦酸组的治疗总有效率为 97.87%,高于传统组的 85.11%,差异有统计学意义(P<0.05);且 2 组均未出现疼痛不良反应.治疗 4 周后 2 组的血清甲状腺旁激素(PTH)、Ⅰ型前胶原氨基端延长肽(PⅠNP)明显高于治疗前,且唑来膦酸组血清PTH、PⅠNP均显著高于传统组,组间差异有统计学意义(P<0.05).2组治疗 4 周后的腰椎L2～4 骨密度均显著高于治疗前,且唑来膦酸组治疗4 周后的腰椎L2～4 骨密度显著高于传统组,差异有统计学意义(P<0.05).2 组治疗 4 周后的骨小梁厚度明显厚于治疗前,骨小梁距离明显短于治疗前,且唑来膦酸组骨小梁厚度厚于传统组,骨小梁距离短于传统组,组间差异有统计学意义(P<0.05).结论:唑来膦酸治疗老年骨质疏松能提高治疗效果,改善患者的骨密度,且不会增加疼痛不良反应的发生,缩短患者的骨小梁距离,增加患者的骨小梁厚度.
Abstract
Objective:To investigate and analyze the therapeutic effect of Zoledronic Acid in the treatment of elderly osteoporosis.Methods:94 osteoporosis patients diagnosed and treated in Jianhu County People's Hospital from January 2021 to February 2022 were selected as the study objects.They were rendomly divided into a Zoledronic Acid group and a traditional group,with 47 patients in each group.The traditional group was given conventional drug treatment,and the Zoledronic Acid group was given Zoledronic Acid treatment on the basis of the traditional group treatment.Both groups were treated and observed for 4 weeks.The clinical efficacy,pain and bone metabolism of the two groups were recorded.Results:After 4 weeks of treatment,the total effective rate of the Zoledronic Acid group was 97.87%,which was higher than 85.11%of the traditional group,and the difference between groups was statistically significant(P＜0.05).There was no adverse reaction of pain in the two groups.The serum parathyroid hormone(PTH)and amino terminal procollagen typeⅠprocollagen lengthening peptide(PⅠNP)in the two groups after 4 weeks of treatment were significantly lower than those before treatment,and the serum PTH and PⅠNP in the Zoledronic Acid group were significantly higher than those in the traditional group,with statistical significance between the two groups(P＜0.05).The bone mineral density of L2～4 of lumbar spine after 4 weeks of treatment in two groups were significantly higher than those before treatment,and the bone mineral density of L2～4 of lumbar spine after 4 weeks of treatment in the Zoledronic Acid group was significantly higher than that of the traditional group,with statistical significance(P＜0.05).After 4 weeks of treatment,the trabecular thickness of the two groups were significantly thicker than those before treatment,and the trabecular distance of the two groups were significantly shorter than those before treatment(P＜0.05).After 4 weeks of treatment,the bone trabecular thickness in the Zoledronic Acid group was thicker than that in the traditional group,and the bone trabecular distance in the Zoledronic Acid group was shorter than that in the traditional group,with statistical significance between the two groups(P＜0.05).Conclusion:Zoledronic Acid in the treatment of elderly osteoporosis can improve the therapeutic effect,improve the bone density of patients,and does not increase the occurrence of pain adverse reactions,shorten the trabecular distance of patients,increase the trabecular thickness of patients.
关键词
骨质疏松/唑来膦酸/老年人/骨密度/疼痛不良反应/骨代谢/骨小梁距离Key words
Osteoporosis/Zoledronic Acid/Elderly/Bone density/Pain adverse reactions/Bone metabolism/Bone trabecular distance引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
万方数据