骨化三醇对长期维持血液透析的肾性骨病患者预后的影响
Effect of Calcitriol on the Prognosis of Patients with Renal Osteopathy on Long-Term Maintenance Hemodialysis
李娜1
作者信息
- 1. 天津市北辰医院血透室,天津 300400
- 折叠
摘要
目的:探讨骨化三醇对长期维持血液透析的肾性骨病患者近远期预后的影响.方法:选择该院 2020年 2月—2022年 3月进行长期血液透析的208例肾性骨病患者为研究对象,按随机数字表法将其分为对照组与观察组,各104例.对照组在透析期间采用常规辅助治疗,观察组在对照组基础上采用骨化三醇治疗,2组均连续治疗 12周.对比 2组血钙、血磷含量、肾功能、并发症发生情况、生活质量.结果:治疗 12周后,观察组血钙含量高于对照组,血磷含量低于对照组,组间差异有统计学意义(P<0.05).2组血清尿素氮、肌酐含量均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05).观察组并发症总发生率为 3.80%,低于对照组的 12.50%,差异有统计学意义(P<0.05).观察组生活质量的各个维度评分均高于对照组,组间差异有统计学意义(P<0.05).结论:长期维持血液透析的肾性骨病患者采用骨化三醇治疗,可改善患者肾功能,提高血钙含量,降低血磷含量,降低并发症发生率,改善患者长期生活质量.
Abstract
Objective:To explore the effect of calcitriol on the short-term and long-term prognosis of patients with renal bone disease who maintained hemodialysis for a long time.Methods:208 patients with renal bone disease who underwent long-term hemodialysis in the hospital from February 2020 to March 2022 were selected as the study objects,and were divided into a control group and an observation group according to random number table method,with 104 cases in each group.The control group was treated with routine adjuvant treatment during dialysis,and the observation group was treated with calcitriol on the basis of the control group.Both groups were treated continuously for 12 weeks.Blood calcium,blood phosphorus content,kidney function,complications,quality of life were compared between the two groups.Results:After 12 weeks of treatment,the blood calcium content in the observation group was higher than that in the control group,and the blood phosphorus content was lower than that in the control group,with statistical significance(P<0.05).Serum urea nitrogen and creatinine contents in 2 groups were lower than before treatment,and observation group was lower than control group,the differences were statistically significant(P<0.05).The total incidence of complications in the observation group was 3.80%,which was lower than 12.50%in the control group,and the difference was statistically significant(P<0.05).The quality of life scores of the observation group were higher than those of the control group,and the difference between the groups was statistically significant(P<0.05).Conclusion:Treatment with calcitriol can improve renal function,increase blood calcium content,reduce blood phosphorus content,reduce the incidence of complications and improve long-term quality of life of patients with renal osteopathy who are maintained on hemodialysis for a long time.
关键词
肾性骨病/骨化三醇/血液透析Key words
Renal bone disease/Calcitriol/Hemodialysis引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
万方数据