Effect of Intramedullary Nailing and Plate Fixation on Tibial Fractures and Their Effects on Bone Metabolism and Inflammatory Factors
Objective:To investigate the effect of intramedullary nail and plate fixation on tibial fracture and the effect on bone metabolism and inflammatory factors.Methods:The data of 60 patients with tibial fracture treated in our hospital from January 2018 to December 2020 were retrospectively analyzed,and they were divided into locking compression plate(LCP)group and interlocking intramedullary nail(IMN)group,with 30 cases each,according to different treatment methods.The LCP group was treated with LCP and the IMN group was treated with IMN.The clinical efficacy,postoperative recovery,bone metabolism and inflammatory factor levels,and operative complications were compared between the two groups.Results:The effective rate of IMN group was 93.33%,which was higher than 73.33%of control group,the difference was statistically significant(P<0.05).In IMN group,the operation,starting weight bearing and fracture healing time were all shorter than those in LCP group,the amount of surgical bleeding was more than that in LCP group,and the scores of Olerud and Molander|ankle fracture efficacy scoring system and the modified American Hospital for Special Surgery Knee Scoring system were all higher than those in LCP group 1 and 3 months after operation,the differences between groups were statistically significant(P<0.05).The levels of osteocalcin,osteoclast inhibitory factor and protocollagen type I N-terminal propeptide in IMN group were higher than those in LCP group,urinary deoxypyridinol,tartrate-resistant acid phosphatase and cathepsin K were lower than those in LCP group,and the levels of interleukin-35 and transforming growth factor-β in IMN group were higher than those in LCP group.Tumor necrosis factor-α and gamma interferon were lower than LCP group,and the differences were statistically significant(P<0.05).Conclusion:IMN is better than LCP in the treatment of tibial fracture the recovery was better,which was conducive to the improvement of bone metabolism and inflammatory factors.
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