Effect of Internal Fixation Combined with Artificial Vertebroplasty on Spinal Fracture and Its Effect on HIF-1α and MMP-2
Objective:To explore the effect of internal fixation combined with artificial bone vertebroplasty in the treatment of spinal fractures,and to analyze the effect of intervention on the levels of hypoxia-inducible factor-1α(HIF-1α)and matrix metalloproteinase-2(MMP-2).Methods:80 patients with spinal fractures treated in our hospital from January 2020 to October 2022 were selected as the research objects.According to the difference in surgical methods,they were divided into a study group and a control group,with 40 cases in each group.The study group received internal fixation combined with artificial bone vertebroplasty,and the control group received internal fixation surgery.The clinical efficacy,perioperative indicators,and levels of inflammatory factors before and 7 days after operation were compared between the two groups.The patients were followed up for 6 months,and the differences in thoracolumbar bone mineral density(T value),Beck index and Cobb Angle were compared between the two groups.Results:The total effective rate of the study group was 95.00%,which was higher than 80.00%of the control group,the difference was statistically significant(P<0.05).The postoperative out-of-bed time and hospitalization time of the study group were shorter than those of the control group,and the differences between the two groups were statistically significant(P<0.05).There were no statistically significant differences in the operation time and intraoperative blood loss between the two groups(P>0.05).At 3 and 6 months of follow-up,the T values of thoracolumbar bone mineral density of the study group were higher than those of the control group,and the differences between the two groups were statistically significant(P<0.05).The Cobb Angle of the study group was less than that of the control group,and the Beck index was higher than that of the control group,and the differences between the two groups were statistically significant(P<0.05).There was no significant difference in the serum levels of HIF-1α and MMP-2 between the two groups at 1 day before operation(P>0.05).On the 7th day after operation,the levels of serum HIF-1α and MMP-2 in the two groups were higher than those before operation,but the levels of serum HIF-1α and MMP-2 in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).Conclusion:The combination of internal fixation and artificial bone vertebroplasty for patients with spinal fractures has a good clinical effect,which can help to improve the inflammatory state of patients and has positive significance for improving the short-term spinal function of patients after operation.
Artificial bone vertebroplastyInternal fixationClinical efficacySerum inflammatory factorsAngle of Cobb
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