不同范围的INR对应用华法林的老年患者的影响
Effects of Different Ranges of INR on Elderly Patients Receiving Warfarin
赵玉红 1李艳 2陆华岭 3颜蕾 3史嘉炜 1宁思思 1陈剑锋 4郁惠英5
作者信息
- 1. 上海市长宁区天山中医医院内科,上海 200051
- 2. 上海市长宁区天山中医医院科教科
- 3. 上海市长宁区天山中医医院医务科
- 4. 上海国际医学中心
- 5. 上海市松江区泗泾医院
- 折叠
摘要
目的:探究不同范围的INR对应用华法林的老年患者的影响,及其临床疗效及其安全性.方法:选取 2019年1月—2020年 12月我院内科住院治疗的 100例老年非瓣膜病房颤患者为研究对象,随机分为对照组和研究组,各 50例.对照组INR维持在 1.6～2.0,研究组INR维持在 2.1～2.6,根据INR值调整华法林剂量.各组INR达到目标值前每周监测 1次INR.INR稳定后每 4周监测 1次.观察比较 2组临床疗效及出血栓塞等不良事件发生率.结果:2组出血发生情况比较,差异无统计学意义(P>0.05);研究组不良事件发生率、NT-proBNP水平均低于对照组,组间差异有统计学意义(P<0.05).结论:INR控制在 2.1～2.6时,在预防老年人非瓣膜性房颤临床栓塞等不良事件的发生,保护血管内皮预防血栓形成的同时,可进一步改善患者心功能.
Abstract
Objective:To explore the effects of different ranges of INR on elderly patients treated with warfarin,its clinical efficacy and safety.Methods:100 elderly patients with nonvalvular atrial fibrillation hospitalized in our hospital from January 2019 to December 2020 were selected as the study objects and randomly divided into a control group and a study group,with 50 cases in each group.The INR of the control group was maintained at 1.6～2.0,and the INR of the study group was maintained at 2.1～2.6.The warfarin dose was adjusted according to the INR value.The INR of each group was monitored once a week before reaching the target value.The INR was monitored every 4 weeks after stabilization.The clinical efficacy and incidence of adverse events such as bleeding embolization were observed and compared between the two groups.Results:There was no significant difference in the occurrence of hemorrhage between the two groups(P>0.05).The incidence of adverse events and the level of NT-proBNP in the study group were significantly lower than those in the control group(P<0.05).Conclusion:When INR is controlled in the range of 2.1～2.6,it can prevent clinical embolism and other adverse events in elderly patients with NVAF,protect vascular endothelium to prevent thrombosis,and further improve the cardiac function of patients.
关键词
INR/不同范围/华法林/老年患者/心功能Key words
INR/Different ranges/Warfarin/Elderly patients/Cardiac function引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
万方数据