Effect of Metformin Combined with Atorvastatin Calcium in Patients with Type 2 Diabetes Mellitus Complicated with Fatty Liver
Objective:To investigate the effect of Metformin combined with Atorvastatin Calcium in type 2 diabetes mellitus(T2DM)patients with fatty liver.Methods:A total of 80 T2DM with fatty liver disease patients admitted to Xingan Hospital of Traditional Chinese Medicine from January 2021 to June 2022 were selected as the study objects,and the patients were divided into a Metformin group and a combined treatment group according to random number table method,with 40 cases in each group.The Metformin group was treated with Metformin,and the combined treatment group was treated with Metformin and Atorvastatin Calcium.The clinical efficacy,glucose and lipid metabolism indexes,vascular endothelial function and conditions of prognosis were compared between the two groups.Results:The total effective rate of combined treatment group was 95.00%,which was higher than 80.00%of the Metformin group,the difference was statistically significant(P<0.05).After treatment,insulin resistance index,triglyceride and total cholesterol in 2 groups were lower than before treatment,the combined treatment group was lower than the Metformin group,the differences were statistically significant(P<0.05);the endothelin in both groups was lower than before treatment,nitric oxide was higher than before treatment,and the endothelin of the combined treatment group was lower than that of the Metformin group,nitric oxide was higher than that of the Metformin group,the differences were statistically significant(P<0.05).The incidence of adverse prognosis in the combined treatment group was 1.67%,which was lower than 15.00%in the Metformin group,the difference was statistically significant(P<0.05).Conclusion:Metformin combined with Atorvastatin Calcium are effective in T2DM patients with fatty liver,and can effectively improve glucose and lipid metabolism and vascular endothelial function,and have good security.
Type 2 diabetes mellitus with fatty liverMetformin combined with Atorvastatin Calcium therapyGlucose metabolismLipid metabolism
国家科技期刊平台
NSTL
万方数据
