Effects of Propofol on Postoperative Cognitive Dysfunction and Early Oxidative Stress Indexes in Patients with Joint Replacement
Objective:To evaluate the effects of Propofol on postoperative cognitive dysfunction and early oxidative stress in patients with joint replacement.Methods:Data of 92 joint replacement patients admitted to The Second Affiliated Hospital of Shandong First Medical University from January 2022 to January 2024 were retrospectively analyzed and divided into a study group and a control group according to different anesthesia methods,46 cases in each group.Sevoflurane was used to maintain anesthesia in the control group and Propofol was used to maintain anesthesia in the study group.Cognitive dysfunction,oxidative stress and adverse reactions were compared between the two groups.Results:Twenty-four hours after operation,the Mini-Mental State Examination scores in the control group was lower than that in the study group,the difference was statistically significant(P<0.05).the incidence of postoperative cognitive dysfunction in the study group was 4.35%,which was lower than 19.57%in the control group,the difference was statistically significant(P<0.05).Twenty-four hours after surgery,malondialdehyde and 8-hydroxy-deoxyguanosine level in both groups were higher than before surgery,but the study group was lower than the control group;superoxide dismutase level in both groups was lower than before treatment,but the study group was higher than the control group,with statistical significance(P<0.05).The incidence of adverse reactions in the study group was 4.35%,lower than 8.70%in the control group,but there was no significant difference between the two groups(P>0.05).Conclusion:Propofol has a positive effect on postoperative cognitive dysfunction and early oxidative stress in patients with joint replacement surgery,which can reduce the incidence of postoperative cognitive dysfunction and alleviate early oxidative stress reaction with good safety.
万方数据
维普
