Objective:To evaluate the value of computed tomography(CT)and magnetic resonance imaging(MRI)in the differential diagnosis of benign and malignant vertebral compression fractures(VCFs).Methods:A total of 98 VCFs patients admitted to the Third People's Hospital of Jinan from June 2021 to May 2024 were selected as the study objects.All 98 patients received CT and MRI examinations after admission.Using pathological findings as the"gold standard",the differential diagnosis results of CT and MRI for VCFs were evaluated and the specificity,sensitivity and accuracy of diagnosis were compared.Meanwhile,the imaging features of benign and malignant VCFs patients were compared(Jumping involvement,continuous involvement,wedge-shaped,biconcave,posterior angular protrusion,posterior bulging).Results:Among the 98 VCFs patients,48 cases(48.98%)were malignant and 50 cases(51.02%)were benign,among which 47 cases(47.96%)were malignant by CT and 48 cases(48.98%)were malignant by MRI.The specificity,sensitivity and accuracy of MRI for differential diagnosis of benign and malignant VCFs patients were 98.00%,97.92%and 97.96%,higher than 82.35%,82.98%and 82.65%of CT,with statistical significance(P<0.05).In the imaging features of the affected vertebra,the incidence of jump involvement,posterior marginal angular prominences and posterior marginal swelling in the malignant group was 62.82%,41.67%and 19.23%respectively,which were higher than 36.36%,1.21%and 1.21%in the benign group,and the incidence of continuous involvement was 41.67%,which was lower than 71.52%in the benign group,the differences were statistically significant(P<0.05).The incidence of wedge shape and double concave shape was 64.10%and 10.26%in the malignant group,and there was no statistical significance compared with 61.82%and 10.91%in the benign group(P>0.05).Conclusion:The imaging features of benign and malignant VCFs patients are different,and MRI is more valuable than CT in differentiating benign and malignant VCFs,it can provide reliable reference information for clinical follow-up diagnosis and treatment.