Application of 2012 and 2021 CKD-EPI Glomerular Filtration Rate Formula in Patients with Stage 2 to 3 Chronic Kidney Disease
Objective:To compare the application of glomerular filtration rate formula in patients with stage 2～3 chronic kidney disease(CKD-EPI)in the 2012 and 2021 Collaborative Study on Epidemiology of Chronic Kidney Disease(CKD-EPI).Methods:A total of 100 patients with stage 2～3 chronic kidney disease admitted to the South Hospital of Qiqihar First Hospital from April 2022 to March 2024 were selected as the study objects.GFR reference value(rGFR),serum creatinine(Ser)and cystatin C(Cys C)were determined for all patients.The 2012 and 2021 CKD-EPI glomerular filtration rate formulas were used to calculate the estimated GFR(eGFR),and the consistency of eGFR and rGFR calculated by the two formulas was analyzed.Results:The relationship between eGFR and rGFR calculated by the four formulas was roughly linear.The MSE value obtained by the two CKD-EPI Scr-Cys C formula was smaller than that obtained by the CKD-EPI Scr formula,and the MSE value obtained by the 2012 CKD-EPI Scr-Cys C formula was smaller than that obtained by the 2021 CKD-EPI Scr C formula,with statistical significance(P<0.05).The area under the curve(AUC)value obtained by the two CKD-EPI Scr-Cys C formulas was greater than that obtained by the CKD-EPI Scr formula,and the AUC value obtained by the 2012 CKD-EPI Scr-Cys C formula was greater than that obtained by the 2021 CKD-EPI Scr C formula,with statistical significance(P<0.05).Bland-Altman analysis results showed that the 2012 CKD-EPI Scr-Cys C formula had the smallest deviation and accuracy,while the 2021 CKD-EPI Scr formula had the largest deviation and accuracy,the differences were statistically significant(P<0.05).Analysis of eGFR values in the rGFR ranges of 15%,30%and 50%showed that the CKD-EPI Scr-Cys C formula was higher than the CKD-EPI Scr formula,and two formulas of the 2012 version were higher than those of the 2021 version.Kappa test was performed to analyze the staging diagnostic efficiency of eGFR values and rGFR values calculated by the four formulas.The results showed that the 2012 version of CKD-EPI Scr-Cys C formula had the highest staging diagnostic accuracy and Kappa value,and the staging diagnostic efficiency was the best.Compared with the Scr formula,the two versions of CKD-EPI Scr-Cys C formula had higher diagnostic accuracy and Kappa value,and better stage diagnosis efficiency,with statistical significance(P<0.05).Conclusion:The 2012 version of CKD-EPI Scr-Cys C formula is more suitable for stage 2～3 chronic kidney disease patients,and has the best stage diagnosis efficiency.The 2012 and 2021 versions of CKD-EPI Scr-Cys C formula are better than CKD-EPI Scr formula in staging diagnosis.
万方数据
维普
