Observation of the Effect of Early Abdominal Puncture Drainage in the Treatment of Patients with Severe Acute Pancreatitis
Objective:To analyze the effect of early abdominal puncture and drainage(APD)in patients with severe acute pancreatitis(SAP).Methods:Data of 94 SAP patients admitted to Tai'an Central Hospital from September 2022 to September 2023 were retrospectively analyzed.According to the different duration of APD treatment,they were divided into a control group and a study group,with 47 cases in each group.The control group received APD 72 h after onset,and the study group received APD within 72 h after onset.The inflammatory indexes,the levels of endogenous antioxidant pathway factors and the incidence of complications were compared between the two groups.Results:One week after surgery,interleukin-6 level was(30.46±2.58)pg/mL,C-reactive protein level was(7.63±1.02)mg/L,tumor necrosis factor-α level was(0.75±0.19)ng/mL,and procalcitonin level was(0.59±0.10)μg/L in the study group,which were lower than(41.21±3.29)pg/mL,(10.24±1.59)mg/L,(1.31±0.53)ng/mL,(1.01±0.22)μg/L in the control group,the differences were statistically significant(P<0.05).One week after surgery,the positive expression rate of nuclear factor E2-related factors in study group was 87.23%,and the level of heme oxygenase-1 was(46.88±4.25)pg/mL,which were higher than 68.09%and(32.59±3.48)pg/mL in control group,with statistical significance(P<0.05).The incidence of complications in the study group was 4.26%,which was lower than 17.02%in the control group,the difference was statistically significant(P<0.05).Conclusion:Early APD can effectively control the inflammatory response in SAP patients,improve the level of endogenous antioxidant pathway factors,and the incidence of complications is less,which has certain application value.
Severe acute pancreatitisEarly abdominal puncture and drainageInflammatory reactionComplications
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