Objective:To analyze the effect of early abdominal puncture and drainage(APD)in patients with severe acute pancreatitis(SAP).Methods:Data of 94 SAP patients admitted to Tai'an Central Hospital from September 2022 to September 2023 were retrospectively analyzed.According to the different duration of APD treatment,they were divided into a control group and a study group,with 47 cases in each group.The control group received APD 72 h after onset,and the study group received APD within 72 h after onset.The inflammatory indexes,the levels of endogenous antioxidant pathway factors and the incidence of complications were compared between the two groups.Results:One week after surgery,interleukin-6 level was(30.46±2.58)pg/mL,C-reactive protein level was(7.63±1.02)mg/L,tumor necrosis factor-α level was(0.75±0.19)ng/mL,and procalcitonin level was(0.59±0.10)μg/L in the study group,which were lower than(41.21±3.29)pg/mL,(10.24±1.59)mg/L,(1.31±0.53)ng/mL,(1.01±0.22)μg/L in the control group,the differences were statistically significant(P<0.05).One week after surgery,the positive expression rate of nuclear factor E2-related factors in study group was 87.23%,and the level of heme oxygenase-1 was(46.88±4.25)pg/mL,which were higher than 68.09%and(32.59±3.48)pg/mL in control group,with statistical significance(P<0.05).The incidence of complications in the study group was 4.26%,which was lower than 17.02%in the control group,the difference was statistically significant(P<0.05).Conclusion:Early APD can effectively control the inflammatory response in SAP patients,improve the level of endogenous antioxidant pathway factors,and the incidence of complications is less,which has certain application value.
关键词
重症急性胰腺炎/早期腹腔穿刺引流术/炎症反应/并发症
Key words
Severe acute pancreatitis/Early abdominal puncture and drainage/Inflammatory reaction/Complications
维普
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