Effect of Danxiang Guanxin Injection Combined with Ticagrelor and Indobuprofen in the Treatment of Patients with Myocardial Infarction
Objective:To observe the effect of Danxiang Guanxin Injection combined with Ticagrelor and Indobuprofen in patients with myocardial infarction(MI).Methods:A total of 118 patients with MI admitted in Ganxian District People's Hospital from March 2023 to February 2024 were selected as the study objects,and randomly divided into a control group and a study group,with 59 cases in each group.The control group was treated with Ticagrelor and Indobuprofen,and the study group was treated with Danxiang Guanxin Injection based on the control group.The clinical efficacy,coronary blood flow,cardiac function indexes,serum amyloid A1(SAA1),soluble leukocyte differentiation antigen 40 ligand(sCD40L),soluble growth stimulation-expressed gene 2 protein(sST2)and the occurrence of adverse reactions were compared between the two groups.Results:The total effective rate of the study group was 94.92%,which was higher than 83.05%of the control group,the difference was statistically significant(P<0.05).After treatment,the left anterior descending branch diastolic peak velocity(DPV),systolic peak velocity(SPV)and coronary flow reserve(CFVR)in both groups were higher than before treatment,and the study group were higher than the control group,the differences were statistically significant(P<0.05).After treatment,the levels of cardiac output(CO),cardiac output index(CI)and left ventricular ejection fraction(LVEF)in both groups were higher than before treatment,and the level of left ventricular end-systolic inner diameter(LVESD)was lower than before treatment,and the levels of CI,CO and LVEF in the study group were higher than those in the control group,and the level of LVESD was lower than that in the control group,the differences were statistically significant(P<0.05).After treatment,serum levels of SAA1,sCD40L and sST2 in two groups were lower than before treatment,and the study group was lower than the control group,with statistical significance(P<0.05).The incidence of adverse reactions in the study group was 16.95%,compared with 8.47%in the control group,the difference was not statistically significant(P>0.05).Conclusion:Danxiang Guanxin Injection combined with Ticagrelor and Indoubuprofen has obvious effect in the treatment of MI patients,which can improve coronary blood flow,enhance cardiac function,and reduce serum levels of SAA1,sCD40L and sST2,with high safety.
Myocardial infarctionDanxiang Guanxin InjectionTicagrelorIndobuprofenCoronary blood flowCardiac function
万方数据
维普
