Effects of Remimazolam Anesthesia on Stress Response and Immune Function in Patients Undergoing Laparoscopic Cholecystectomy
Objective:To investigate the effect of Remimazolam anesthesia in laparoscopic cholecystectomy.Methods:A total of 132 patients undergoing laparoscopic cholecystectomy in Yudu County People's Hospital from June 2021 to June 2024 were selected as the study objects,and were divided into a Remimazolam group and a Midazolam group by drawing lots,with 66 cases in each group.The Midazolam group was induced by Midazolam anesthesia,while the Remimazolam group was induced by Remimazolam anesthesia.The hemodynamic level,recovery time,stress response,immune function and the occurrence of adverse reactions were compared between the two groups.Results:At induction,immediately after intubation and 1 min after intubation,the heart rate and mean arterial pressure in the Remimazolam group were lower than those in the Midazolam group,the differences were statistically significant(P<0.05).The anesthesia recovery time,extubation time and stay time in anesthesia ICU in the Remimazolam group were shorter than those in the Midazolam group,the differences were statistically significant(P<0.05).1 and 3 days after surgery,the levels of norepinephrine and cortisol in the Remimazolam group were lower than those in the Midazolam group,the differences were statistically significant(P<0.05).1 and 3 days after surgery,the CD4+levels in the Remimazolam group were higher than those in the Midazolam group,while the CD8+levels were lower than those in the Midazolam group,the differences were statistically significant(P<0.05).The incidence of adverse reactions in the Remimazolam group was 3.03%,which was lower than 19.70%in the Midazolam group,the difference was statistically significant(P<0.05).Conclusion:Remimazolam in laparoscopic cholecystectomy can maintain the hemodynamic stability of patients,reduce the impact of stress response and immune function,shorten the recovery time,and have high anesthesia safety.
Laparoscopic cholecystectomyRemimazolamStress responseImmune function
万方数据
维普
