血清性激素及甲状腺相关激素水平与围绝经期2型糖尿病合并骨质疏松症或骨量减少患者的相关性研究

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中文摘要：目的:研究血清性激素、甲状腺相关激素水平与围绝经期 2型糖尿病合并骨质疏松症或骨量减少患者的相关性。方法:选取 2022年 1月—2023年 12月黄骅开发区博爱医院收治的 158例围绝经期 2型糖尿病患者为研究对象，将骨质疏松症或骨量减少患者纳入研究组(n=78)，非骨质疏松症或骨量减少患者纳入对照组(n=80)。探究血清性激素、甲状腺相关激素水平与绝经期 2型糖尿病患者发生骨质疏松症及骨量减少情况的相关性。结果:研究组雌激素、孕酮、游离三碘甲状腺原氨酸、血清游离甲状腺素水平均低于对照组，卵泡刺激素、黄体生成素、血清促甲状腺激素水平均高于对照组，差异均有统计学意义(P<0。05)。研究组骨质疏松症及骨量减少的发生风险评分均高于对照组，差异均有统计学意义(P<0。05)。雌激素、孕酮、游离三碘甲状腺原氨酸、血清游离甲状腺素水平与骨质疏松症和骨量减少呈负相关，卵泡刺激素、黄体生成素、血清促甲状腺激素水平与骨质疏松症和骨量减少呈正相关。结论:在围绝经期 2型糖尿病患者中，雌激素、孕酮、游离三碘甲状腺原氨酸、血清游离甲状腺素与其发生骨质疏松症或骨量减少呈负相关，卵泡刺激素、黄体生成素、血清促甲状腺激素水平与其发生骨质疏松症和骨量减少呈正相关。

外文标题：Correlation Between Serum Sex Hormone and Thyroid-Related Hormone Levels and Perimenopausal Type 2 Diabetes Mellitus Patients with Osteoporosis or Bone Mass Loss

外文摘要：Objective:To investigate the correlation between serum sex hormone and thyroid hormone levels and the patients with perimenopausal type 2 diabetes mellitus complicated with osteoporosis or bone mass loss.Methods:A total of 158 patients with perimenopausal type 2 diabetes admitted to Boai Hospital of Huanghua Development Zone from January 2022 to December 2023 were selected as the study objects.Patients with osteoporosis or bone loss were included in the observation group(n=78),and those without osteoporosis or bone loss were included in the control group(n=80).To explore the correlation between serum sex hormone and thyroid related hormone levels and osteoporosis and bone mass loss in menopausal patients with type 2 diabetes.Results:The levels of estrogen,progesterone,free triiodothyronine and serum free thyroxine in observation group were lower than those in control group,while the levels of FSH,luteinizing hormone and serum thyroid stimulating hormone were higher than those in control group,with statistical significance(P<0.05).The risk scores of osteoporosis and bone loss in the observation group were higher than those in the control group,with statistical significance(P<0.05).The levels of estrogen,progesterone,free triiodothyronine and serum free thyroxine were negatively correlated with osteoporosis and bone mass loss,while the levels of FSH,luteinizing hormone and serum thyroid stimulating hormone were positively correlated with osteoporosis and bone mass loss.Conclusion:In perimenopausal patients with type 2 diabetes mellitus,estrogen levels,progesterone,free triiodothyronine and serum free thyroxine are negatively correlated with the development of osteoporosis or bone mass loss,while follicle stimulating hormone,luteinizing hormone and serum thyroid stimulating hormone are positively correlated with the development of osteoporosis and bone mass loss.

外文关键词：

Type 2 diabetes mellitusOsteoporosisDecreased bone massSex hormoneThyroid hormonePeri-menopause

作者：

张雨

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作者单位：

河北省沧州市黄骅开发区博爱医院检验科,河北沧州 061000

关键词：

2型糖尿病骨质疏松症骨量减少性激素甲状腺激素围绝经期

出版年：

2024

DOI：