Effect of Metoprolol Tartrate Combined with Amiodarone on Sinus Rhythm Maintenance and Cardiac Function in Patients with Coronary Heart Disease Complicated by Ventricular Arrhythmia
Objective:To investigate the specific effect of Metoprolol Tartrate combined with Amiodarone in the treatment of coronary heart disease(CHD)with ventricular arrhythmia.Methods:A total of 86 patients with CHD combined with ventricular arrhythmia admitted to Weishan County People's Hospital from February 2022 to February 2024 were selected and randomly divided into a control group and a study group,with 43 patients in each group,according to the random number table method.The control group was treated with amiodarone,while the observation group was treated with metoprolol tartrate in addition to the above.Continuous medication treatment for 4 weeks,observe the clinical efficacy,sinus rhythm maintenance,cardiac function,and adverse reactions of two groups.Results:The total effective rate and sinus rhythm maintenance rate of the study group were higher than those of the control group,the differences were statistically significant(P＜0.05).After 4 weeks of treatment,the left ventricular end systolic volume(47.39±3.56)ml,left ventricular ejection fraction(53.09±5.06)%and left ventricular end diastolic volume(87.78±7.43)ml in the study group were all higher than(43.77±3.02)mL,(48.76±4.89)%,and(80.46±6.78)mL in the control group,and the heart rate in the study group was(63.88±6.07)times/min,lower than(70.61±7.10)times/min in the control group,the differences were statistically significant(P＜0.05).There was no statistically significant difference in adverse reactions between the two groups(P＞0.05).Conclusion:The combination therapy of metoprolol tartrate and amiodarone is effective and precise in the treatment of CHD complicated with ventricular arrhythmia.It can effectively maintain sinus rhythm and significantly improve the patient's cardiac function,which is safe and reliable.
Coronary heart diseaseVentricular arrhythmiaAmiodaroneMetoprololSinus rhythmHeart function
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