Analysis of the Effect of Sequential Plasma Exchange with Dual Plasma Molecular Adsorption System on Patients with HBV Associated Acute-On-Chronic Liver Failure
Objective:To investigate the efficacy of sequential plasma exchange(PE)with double plasma molecular adsorption system(DPMAS)in patients with acute-on-chronic liver failure(ACLF)associated with hepatitis B virus(HBV).Methods:A total of 80 HBV-related ACLF patients admitted to Panzhou People's Hospital from November 2021 to May 2024 were selected as the study objects,and were divided into a control group and a study group according to random number table method,with 40 cases in each group.The control group was treated with PE,and the study group was treated with DPMAS sequential PE.Both groups were treated for 12 weeks.The indexes of liver function,inflammation,improvement and complications were compared between the two groups.Results:After treatment,The levels of aspartate aminotransferase,alanine aminotransferase,albumin,direct bilirubin and total bilirubin in the study group were(51.42±10.12)μmol/L,(55.59±10.14)μmol/L,(24.16±2.05)g/L,(88.86±21.24)μmol/L,(62.63±10.74)μmol/L,respectively.They were lower than the control group(100.02±26.25)μmol/L,(120.26±12.24)μmol/L,(27.11±2.15)g/L,(162.65±36.37)μmol/L,(121.24±12.33)μmol/L,the differences were statistically significant(P＜0.05).After treatment,the levels of C-reactive protein,procalcitonin and interleukin-6 in the study group were(13.14±2.63)mg/L,(0.56±0.12)ng/L and(14.02±2.06)ng/L,respectively.It was lower than that of control group(19.41±3.05)mg/L,(0.77±0.15)ng/L and(19.94±3.15)ng/L,the differences were statistically significant(P＜0.05).The improvement rate of the study group was 75.00%,which was higher than 50.00%of the control group,and the complication rate was 10.00%,which was lower than 27.50%of the control group,with statistical significance(P＜0.05).Conclusion:DPMAS sequential PE therapy in HBV-associated ACLF patients can promote the recovery of liver function,reduce inflammation,reduce the incidence of complications and increase the rate of disease recovery.
万方数据
维普
