Comparison of Effects of Different Doses of Remazolam on Patients with Sacral Canal Block Hemorrhoidectomy
Objective:To compare the effects of different doses of Remazolam on patients with sacral canal block hemorrhoidectomy.Methods:A total of 200 patients with sacral canal block hemorrhoidectomy who were admitted to Huaiyin People's Hospital of Jinan from January 2022 to January 2023 were selected as the study objects and randomly divided into a propofol group(group P),a remazolam low dose group(group R1),a remazolam medium dose group(group R2)and a remazolam high dose group(group R3),with 50 cases in each group.All patients underwent sacral canal blank anesthesia under B-ultrasound guidance.Group P received 2 mg/kg of propofol,followed by 5 mg/(kg·h)of propofol;groups R1,R2 and R3 received 0.05 mg/kg of remazolam,followed by 3,4 and 5 μg/(kg·min)of remazolam,respectively.The time of sedation onset,the number of remedies,the time of recovery and the occurrence of complications were compared among the four groups.Results:The onset time of sedation in R1 group was longer than that in R2 and R3 groups and shorter than that in P group,the number of remedies was higher than that in P,R2 and R3 groups,and the recovery time was shorter than that in P,R2 and R3 groups,with statistical significance(P＜0.05).Before the sedative is administered,there were no significant differences in BIS and MOAA/S scores among the four groups(P＞0.05).After the use of sedative drugs,15 minutes after sedation,and at the end of surgery,the BIS value and MOAA/S score of group R1 were higher than those of groups P,R2 and R3,with statistical significance(P＜0.05).The incidence of adverse events in R1,R2 and R3 groups was 0.00%,4.00%and 26.00%,respectively,which were lower than 64.00%in P group,and the R1 group was lower than R2 and R3 groups with statistical significance(P＜0.05).Conclusion:The sober sedation effect of lower dose remazolam in patients with sacral canal block hemorrhoidectomy is higher than that of higher dose remazolam,which can shorten the postoperative recovery time and reduce the occurrence of adverse events.However,the effective time of anesthesia is relatively long,and clinical selection should be based on the patient's situation.
万方数据
维普
