Chemical constituents of Curcuma xanthorrhiza Roxb.and their acetylcholinesterase inhibitory activity
Chemical constituents from Curcuma xanthorrhiza Roxb.( Zingiberaceae) rhizome were isolated and purified by column chromatography ( silica gel, RP-silica gel MPLC, HPLC) and their structures were elucidated on the basis of spectral analyses.Six compounds were identified by MS and NMR spectroscopy as zederone(Ⅰ), β-sitosterol(Ⅱ), Guai-1(10),3,5,7(11),8-pentaen-2-on-11,8-olide(Ⅲ), Curcumadione(Ⅳ), Curcumenone (Ⅴ), Cuparenol (Ⅵ). CompoundⅢand Ⅵwere isolated for the first time from the plants of Zingiberaceae, and compound Ⅳand Ⅴ were isolated from Curcuma xanthorrhiza Roxb.for the first time.Meanwhile, the acetylcholinesterase inhibitory activity of the isolated compounds was evaluated.CompoundsⅣandⅥshowed certain inhibitory activity, the minimum inhibito-ry quantity ofⅣon TLC bioautography test was 95μg.
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