Preparation of Cytarabine Complex Based on Montmorillonite-Loaded
Objective:To design and prepare cytarabin-montmorillonite complex.Methods:Sodium montmorillonite was organically modified with polyethylene glycol and cytarabine-montmorillonite complex was prepared.The structures of the prepared compounds were characterized by X-ray diffraction(XRD),Fourier infrared spectroscopy(FT-IR)and thermogravimetric analysis(TG-DTG).HPLC was used to calculate the amount of free Cytarabine,so as to calculate the drug load of Cytarabine in Montmorillonite.Results:The structural characterization analysis(XRD,FT-IR,TG-DTG)showed that the Cytarabine Montmorillonite complex was successfully prepared.The drug load of Cytarabine in Montmorillonite is 1.42%±0.01%.Conclusion:Cytarabine is inserted into the interlayer of Montmorillonite through structural characterization analysis.The research results provide a reference basis for the preparation of novel Cytarabine Montmorillonite sustained release and theoretical support for its pharmacological research.
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