Objective:To investigate the effect and mechanism of Platycodon grandiflorus extract on skin pigmentation.Methods:The scavenging effect of Platycodon grandiflorus extract on DPPH free radical was studied by free radical scavenging experiment,and the effect of Platycodon grandiflorus extract on skin pigmentation was studied by tyrosinase inhibition experiment in vitro and zebrafish melanin model experiment.Finally,the mechanism of active components of Platycodon grandiflorus in improving skin pigmentation was explored by network pharmacology.Results:Platycodon grandiflorus extract had significant antioxidant and tyrosinase inhibition activities,and also had significant improvement effect on zebrafish pigmentation.Network pharmacology studies showed that Platycodon grandiflorus extract may improve pigmentation by regulating cell targets such as AKT1,TYR and IL-6,and regulating PI3K-AKT and lipid metabolism.Conclusion:Platycodon grandiflorum extract has the effect of improving pigmentation.
维普
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