Nerve membrane potential is an electrical phenomenon that affects cellular lifespan the potential difference between the two sides of the cell membrane,allowing monitoring of membrane potential and neural activity.The combination of mixed optical probe technology and neural membrane potential imaging has the advantages of high fidelity and long-term monitoring,and is widely used in the fields of biophysics,cell biology,and biochemistry.This article summarizes the application of mixed optical probes in imaging neural activity both in vitro and in vivo,explains the design strategy and voltage sensing mechanism of mixed optical probes,and prospects the challenges and prospects of mixed optical probe design and application in the future.
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