Synthesis and Bioactivities of Diaryl-substituted Thiourea by Continuous Reaction
Nine diphenylthiourea derivative were synthesized from substituted aniline by means of continuous feeding.Their structures were characterized by Elemental analysis,MS,IR and 1H NMR.Meanwhile,Their biological activities have been measured by paper agar diffusion method.Target compounds were tested for the bioactivity of S.aureus and E.coli.Biological activities are affected by different substituents and concentrations.The test results showed that Compounds of chloro-substituent are good for Antibacterial activity of S.aureus.Specific impacts:o-Cl＞p-Cl＞2,4-two Cl.F-containing compounds are s.beneficial s.to biological activities of E.coli.The diameter of the inhibition zone of the compound 1a was 1.9 cm against S.aureus.These parameters will provide a scientific data for screening and making high activity thiourea compounds.
万方数据
维普
