Evaluation of Uncertainty for Determination of Ephedrine and Pseudoephedrine in Health Products by HPLC-MS/MS
To establish an uncertain evaluation method for determination of ephedrine and pseudoephedrine in health products by HPLC-MS/MS.The uncertain sources were analyzed by constructing mathematical models of ephedrine and pseudoephedrine content.The results show that the main source of uncertainty in the determination of ephedrine and pseudoephedrine is the preparation of standard standard solution and the fitting of standard curve.When the content of ephedrine is 9.850 μg/kg,the extended uncertainty is 0.745 8 μg/kg(k=2).When the content of pseudoephedrine is 9.557 μg/kg,the extended uncertainty is 0.954 7 μg/kg(k=2).
high performance liquid chromatography-tandem mass spectrometryhealth care productsephedrinepseudoephedrineuncertainty
万方数据
维普
