As an important and common organic compounds,amide compounds play an important role in drug development and production,and have positive practical significance for the research of their synthesis methods in the field of pharmaceutical research and development and application.In the traditional synthesis method of amide compounds,the direct coupling of carboxylic acid derivatives is usually used,which is often limited in terms of safety,economy and green performance.With the rapid development of social economy and the continuous progress of science and technology,some new methods and new technologies have emerged,which are gradually applied to the synthesis of amide compounds and greatly enriched the method of amide bond construction.In this paper,the previous reports on the synthesis methods of amide compounds are summarized in order to provide some basis for the effective synthesis of amide compounds in the future.
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