酰胺类化合物合成方法研究综述
Review on Synthesis of Amide Compounds
何彩玉1
作者信息
- 1. 滁州城市职业学院医学院,安徽滁州 239000
- 折叠
摘要
酰胺类化合物作为有机化合物中重要且常见的一类化合物,在药物研发、生产中扮演着重要的角色,对于其合成方法的研究在医药研发、应用领域中有着积极的现实意义.在酰胺类化合物的传统合成方法中,通常主要采用羧酸类衍生物同胺类直接偶联进行,往往在安全性、经济性、绿色性方面应用受限.随着社会经济的快速发展,科学技术的不断进步,不断涌现出一些新的方法、技术,应用于酰胺类化合物的合成中,极大地丰富了酰胺键构建方法.本文总结以往酰胺类化合物合成方法的相关报道,以期为今后酰胺类化合物合成的有效进行提供一定依据.
Abstract
As an important and common organic compounds,amide compounds play an important role in drug development and production,and have positive practical significance for the research of their synthesis methods in the field of pharmaceutical research and development and application.In the traditional synthesis method of amide compounds,the direct coupling of carboxylic acid derivatives is usually used,which is often limited in terms of safety,economy and green performance.With the rapid development of social economy and the continuous progress of science and technology,some new methods and new technologies have emerged,which are gradually applied to the synthesis of amide compounds and greatly enriched the method of amide bond construction.In this paper,the previous reports on the synthesis methods of amide compounds are summarized in order to provide some basis for the effective synthesis of amide compounds in the future.
关键词
酰胺类化合物/合成方法/进展Key words
amide compounds/synthesis method/progress引用本文复制引用
基金项目
安徽省质量工程项目(2021jyxm1038)
滁州城市职业学院质量工程项目(2021jxzyk03)
出版年
2024
NETL
NSTL
万方数据