Research Progress on Co-Crystal and Co-Amorphous Solid Dispersion of Indomethacin
Indomethacin is a classic non-steroidal anti-inflammatory drug.In recent years,the pharmacological effects of indomethacin are expanding and can be used to treat a variety of diseases.However,there are some problems such as poor solubility and low bioavailability.Cocrystallization and co-amorphous techniques have been widely used to improve the solubility and bioavailability of drugs.Therefore,by combing and summarizing the relevant literature,this paper introduces about cocrystal,co-amorphous solid dispersion,preparation methods and characterization technology of indomethacin.
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