Exploring the Mechanism of Action of Formononetin and Its 5 Metabolites in the Treatment of Cardiovascular Diseases Based on Network Pharmacology
Based on network pharmacology and molecular docking methods,this study explores the mechanism of action of formononetin and its 5 metabolites in the treatment of cardiovascular diseases.Using databases such as Pubchem,SwissADME,SwissTargetPrediction,and GeneCards for target prediction and screening of drugs and diseases,Venny2.1.0 was used to collect the intersection of drugs and disease targets,String was used to draw the PPI network diagram of the intersection target,RCSB PDB was used to select the main protein fragments from the active ingredient targets,and then Auto Dock,Pymol,PMW and other databases were used for molecular docking verification,Finally,six main targets for the treatment of cardiovascular diseases with isoflavones were identified.This study lays the foundation for the application of formononetin in the treatment of cardiovascular diseases.
NETL
NSTL
万方数据
