2-芳基喹唑啉衍生物的合成
Synthesis of 2-arylquinazoline Derivatives
李天宇 1周忠泽 1李淑芳 1刘天宇 1张习云 1王洪林1
作者信息
- 1. 荆楚理工学院 化工药学院,湖北 荆门 448000
- 折叠
摘要
喹唑啉类化合物作为药物研发中的优势骨架结构,被广泛用于抗肿瘤药物的研究开发中.尤其是 2-取代喹唑啉类化合物具有多种生理活性,其衍生物的设计合成引起了广大科研工作者的关注.本研究以邻氨基苄胺为起始原料,和不同的芳基醛反应,在碱性条件下,一锅法得到 4 种 2-芳基取代喹唑啉类化合物,目标产物结构经1 H NMR确证.
Abstract
Quinazoline compounds,as advantageous backbone structures in drug development,are widely used in the research and development of anti-tumor drugs.Especially 2-substituted quinoline compounds have various physiological activities.The design and synthesis of 2-substituted quinoline derivatives have attracted the attention of a large number of researchers.This study used o-aminobenzylamine as the starting material and reacted with different aryl aldehydes.Under alkaline conditions,four 2-aryl substituted quinoline compounds were obtained by one pot method.The structure of the target products was confirmed by 1 H NMR.
关键词
2-芳基/喹唑啉/合成Key words
2-aryl/quinoline/synthesis引用本文复制引用
基金项目
国家级大学生科技创新训练项目()
湖北省大学生科技创新训练项目()
出版年
2024
NETL
NSTL
万方数据