喹唑啉类化合物作为药物研发中的优势骨架结构，被广泛用于抗肿瘤药物的研究开发中。尤其是 2-取代喹唑啉类化合物具有多种生理活性，其衍生物的设计合成引起了广大科研工作者的关注。本研究以邻氨基苄胺为起始原料，和不同的芳基醛反应，在碱性条件下，一锅法得到 4 种 2-芳基取代喹唑啉类化合物，目标产物结构经1 H NMR确证。
Synthesis of 2-arylquinazoline Derivatives
Quinazoline compounds,as advantageous backbone structures in drug development,are widely used in the research and development of anti-tumor drugs.Especially 2-substituted quinoline compounds have various physiological activities.The design and synthesis of 2-substituted quinoline derivatives have attracted the attention of a large number of researchers.This study used o-aminobenzylamine as the starting material and reacted with different aryl aldehydes.Under alkaline conditions,four 2-aryl substituted quinoline compounds were obtained by one pot method.The structure of the target products was confirmed by 1 H NMR.
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