Separation of Fenoxaprop Enantiomers by HPLC Column of β-cyclodextrin Metal-organic Framework Material
The synthesis of a novel material for chiral stationary phase in high-performance liquid chromatography(HPLC)by bonding β-cyclodextrin and meta-carboxybenzenesulfonyl chloride as organic ligands,with potassium ions as coordinating ions,onto silica beads(β-CD-MOF-P20@SiO2)was described.In reverse phase chromatography mode,using ammonium acetate triethylamine/acetic acid buffer and acetonitrile as the mobile phase,chromatographic conditions such as mobile phase ratio,buffer pH,concentration,and flow rate were optimized.Under the optimal separation conditions,the resolution reached 9.89.The linear correlation between the chromatographic peak response signals of the two enantiomer pairs and the concentration of the racemate was good in the range of 6.20×10-6 to 2.99×10-4 mol/L(r=0.996 2～0.999 9).A new method for the qualitative,quantitative determination and preparation of fenoxaprop-ethyl single enantiomer was developed
NETL
NSTL
万方数据
